Monoclonal Antibodies as Therapeutic Agents

Monoclonal Antibodies as Therapeutic Agents What are antibodies? Antibodies are lofty for the consumption in drug therapies because they are very item in the functions that they carry out in biological sy foots. They weed be described as Y-shaped proteins that consist of four polypeptide irons. Residing in the accouterments of the Y are two identical light polypeptide bonds and the fore of the Y consists of two heavy polypeptide chains. The light polypeptide chains that read up the arms are referred to as a mythic (Fragment for Antigen Binding) and function by recognising the antibodys target or antigen (antibody generating molecule). The stem of the Y is known as the Fc fortune of the antibody. The stems main graphic token is to communicate with the world immune strategy so that it initiates a series of immunilogical responses. These initiated immunilogical responses include ADCC (Antibody Dependent Cellular Cytotoxicity) in which pilot program human immune system cells bind to the Fc via specific antibody get over song receptors. These immune cells are then signalled to destroy the trespassing(a) entity, a molecule or a whole cell, to which the antibody is bound. The co-occurrence system is another immune response that can be initiated, where a series of blood proteins bind to the Fc and subsequently conjure up remnant of the invading target. An important factor in the efficaciousness of antibody therapeutics is that the Fc portion also provides for the long half-life of the antibody within the blood. The report of antibody research. In the youthful 1800s scientists discovered that blood serum which was interpreted from mice that were immunised (exposed to) with human proteins contained a mixture of mouse antibodies that could be used to combat certain diseases. This, however, was problematic in that at that place was no technology available at the time to arrive at sufficient quantities of... If you loss to get a full essay, pu! t it on our website: OrderCustomPaper.com

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